Super-Enhancers and CTCF in Early Embryonic Cell Fate Decisions
نویسندگان
چکیده
منابع مشابه
Early embryonic cell fate decisions in the mouse.
During development, initially totipotent cells of the embryo specialize to form discrete tissue lineages. The first lineages to form in the mouse are the extraembryonic tissues. Meanwhile, cells that do not become extraembryonic retain a pluripotent fate since they can give rise to all the germ layers of the fetus. Pluripotent stem cell lines have been derived from the fetal lineage at several ...
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During embryonic pattern formation, the main body axes are established and cells of different developmental fates are specified from a single-cell zygote. Despite the fundamental importance of this process, in plants, the underlying mechanisms are largely unknown. We show that expression dynamics of novel WOX (WUSCHEL related homeobox) gene family members reveal early embryonic patterning event...
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Enhancers are regulatory DNA elements that dictate the spatial and temporal patterns of gene expression during development. Recent evidence suggests that the distinct chromatin features of enhancer regions provide the permissive landscape required for the differential access of diverse signalling molecules that drive cell-specific gene expression programmes. The epigenetic patterning of enhance...
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Molecular oxygen has been known to play a critical role in a wide range of biological processes including glycolysis, mitochondrial respiration, angiogenesis, pulmonary functions, and cardiovascular activities. An emerging theme has developed in recent years that oxygen has significant impact on embryonic development, maintenance of stem cells, and cellular differentiation or cell fate decision...
متن کاملSuper-Enhancers in the Control of Cell Identity and Disease
Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers play in biology would be afforded by knowing the constellation of factors that constitute these domains and by identifying super-enhancers across the spectrum of human cell types. We describe here the population of tra...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2021
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.653669